AMMREN

Malaria struggle must not be derailed by COVID-19

Malaria struggle must not be derailed by COVID-19

Countries which suffer from malaria present strikingly low rates of COVID-19 deaths. Given the epidemiological and human interrelations between the two diseases, there is a danger that the global struggle against malaria will suffer from the diversion of resources to deal with the new coronavirus. The exceptional strain that the pandemic is putting on many …

Malaria breakthrough set to change vaccine design

Malaria breakthrough set to change vaccine design

Researchers from the Australian National University (ANU) have discovered a vital clue as to why malaria vaccines keep failing, which could potentially change how vaccines for the deadly disease and others are made. Malaria is a major global killer. But the parasitic disease which is spread to people by mosquitos does not currently have an …

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

Structural basis for RIFIN-mediated activation of LILRB1 in malaria

The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur as they replicate within human blood. Despite risking immune detection, the parasite delivers proteins that bind host receptors to infected erythrocyte surfaces. In the causative agent of the most deadly human malaria, Plasmodium falciparum, RIFINs form the largest erythrocyte surface protein family1. Some RIFINs …

Nigeria: What Kano Must Do to Effectively Tackle Malaria – Experts

Nigeria: What Kano Must Do to Effectively Tackle Malaria – Experts

Year in year out, governments and donor agencies expend huge amounts of resources for treatment and prevention of malaria in Kano State in particular and the country in general, but the problem seems insurmountable. Recently, Civil Society in Malaria Control, Immunisation and Nutrition (ACOMIN), a non-governmental organisation engaged by Catholic Relief Services and funded by …

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Artemisinin-based combination therapy (ACT) has been first-line treatment for uncomplicated Plasmodium falciparum malaria globally for the past 10–15 years and has contributed greatly to a reduction of malaria illnesses and deaths during 2005–2015 (1,2). However, artemisinin resistance emerged in Cambodia during 2008, where it then spread and even developed de novo throughout the Great Mekong …